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[21-23] A multicenter, double-blind, randomized, placebo-controlled study (N = 1612 postmenopausal women with urogenital and sexual complaints) indicates that 25 mcg of estradiol applied vaginally twice a week for a year may significantly improve 6 vaginal symptoms and signs -- vaginal dryness (P < .0001), itching/burning (P < .0001), recurrent vaginitis (P < .0001), petechiae (P < .0002), dyspareunia (P < .0001), and vaginal atrophy (P < .0001) -- and 5 bladder symptoms and signs -- dysuria (P < .003), frequency/nocturia (P < .001), urinary tract infection (P < .034), urinary incontinence (urge) (P < .002), and urinary atrophy (P < .001). [21] Furthermore, cystometry performed at baseline and after 12 months indicates that the maximal cystometric capacity increases from 200 mL to 290 mL (P < .023); the bladder volume at first urgency increases from 140 mL to 180 mL (P < .048); and bladder volume at strong urgency increases from 130 mL to 170 mL (P < .045). Then one time, when I was browsing on the net, I came across FastSize.com.
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